Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 18 |
| PDBID: | 1CIC |
| Chains: | BA_D |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1038/348254a0 |
| Antibody | |
| Antibody: | anti-idiotype E225 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | D1.3 Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1CIC_B|Chain B|PROTEIN (IG HEAVY CHAIN V REGIONS)|Mus musculus (10090) QVQLQQPGSELVRPGASVKLSCKASGYTFTNYWMHWVKQRPGQGLEWIGNIYPGSGDSNYDEKFKSKATLTVDTSSSTAYMQLSGLTSEDSAVYYCARGLAFYFDHWGQGTTLTVSSALTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPEPVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSETVTCSVAHPASSTTVDKKLEPS |
Light Chain: A
Mutation: NULL
| >1CIC_A|Chain A|PROTEIN (IG HEAVY CHAIN V REGIONS)|Mus musculus (10090) DIVMTQSHKFMSTSVGDRVSITCKASQDVRIAVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCQHCGSYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLDSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: D
Mutation: NULL
| >1CIC_D|Chain D|PROTEIN (IG HEAVY CHAIN V REGIONS)|Mus musculus (10090) QVQLKESGPGLVAPSQSLSITCTVSGFSLTGYGVNWVRQPPGKGLEWLGMIWGDGNTDYNSALKSRLSISKDNSKSQVFLKMNSLHTDDTARYYCARERDYRLDYWGQGTTLTVSSASTTPPSVFPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP28 ARG30 ILE31 ALA32 TYR49 TRP50 THR53 SER67 B: LEU100 D: GLY31 TRP52 ASP54 ASN56 ARG99 ASP100 TYR101 ARG102 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
