Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1792 |
| PDBID: | 5V2A |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/chicken/Henan/109/2013(H7N9)), Influenza A virus (A/pigeon/Wuxi/0405007G/2013(H7N9)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.66 |
| Reference: | 10.1172/JCI85317 |
| Antibody | |
| Antibody: | H7.167 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H7N9 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5V2A_H|Chain D[auth H]|Heavy chain of H7.167 antibody|Homo sapiens (9606) QVQLVQSGGGLVQPGGSLRLSCAASGFNFSSYEMNWVRQAPGKGLEWVSYISSSGSTIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCRLLWFGELFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK |
Light Chain: L
Mutation: NULL
| >5V2A_L|Chain C[auth L]|Light chain (kappa) of H7.167 antibody|Homo sapiens (9606) DIVMTQSPDSLAVSLGERATINCKSSQSVLYSSNNKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYYSTPGLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5V2A_A|Chain A|Hemagglutinin|Influenza A virus (A/chicken/Henan/109/2013(H7N9)) (1574512) DKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVDLGQCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQILRESGGIDKEAMGFTYSGIRTNGATSACRRSGSSFYAEMKWLLSNTDNAAFPQMTKSYKNTRKSPALIVWGIHHSVSTAEQTKLYGSGNKLVTVGSSNYQQSFVPSPGARPQVNGLSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASFLRGKSMGIQSGVQVDANCEGDCYHSGGTIISNLPFQNIDSRAVGKCPRYVKQRSLLLATGMKNVPEIPKGR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER27 ASN28 TYR32 TRP50 TYR92 SER93 THR94 H: SER31 GLU33 TYR50 SER52 SER55 THR56 TYR58 TRP96 PHE97 GLY98 GLU99 A: ILE130 ARG131 ASN133 ASN157 ASN158 ALA159 ALA160 PHE161 PRO162 GLN163 ALA189 THR192 LYS193 GLY196 SER197 GLY198 ASN199 LYS200 ASN248 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
