Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1788 |
| PDBID: | 5UTZ |
| Chains: | HL_D |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.75 |
| Reference: | 10.1038/s41591-018-0070-2 |
| Antibody | |
| Antibody: | 5111 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-2 |
| Antigen mutation: | No |
| Durg Target: | P60568 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5UTZ_H|Chain A[auth B], D[auth F], G[auth H], J|Fab 5111 heavy chain|Homo sapiens (9606) QLQLQESGPGLVKPSQTLSLTCTVSGGSISSGGYYWSWIRQHPGKGLEWIGYIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARTPTVTGDWFDPWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >5UTZ_L|Chain B[auth C], E[auth G], H[auth K], K[auth L]|Fab 5111 light chain|Homo sapiens (9606) NFMLTQPHSVSESPGKTVTISCTRSSGSIASNYVQWYQQRPGSSPTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSNVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: D
Mutation: NULL
| >5UTZ_D|Chain C[auth A], F[auth D], I[auth E], L[auth I]|Interleukin-2|Homo sapiens (9606) APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY32 TYR35 TRP49 TYR52 TYR54 TYR55 SER56 GLY57 SER58 THR59 TYR60 TYR61 LYS66 THR102 VAL103 THR104 GLY105 ASP106 L: ALA30 SER31 ASN32 TYR33 ASP52 TYR94 ASP95 SER96 SER97 ASN98 D: HIS16 LEU19 ASP20 MET23 GLY27 ASN71 GLN74 SER75 LYS76 ASN77 PHE78 HIS79 LEU80 ARG81 PRO82 ARG83 ASP84 LEU85 ASN88 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
