Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1777 |
| PDBID: | 5UQY |
| Chains: | PO_M |
| Organism: | Ravn virus - Ravn, Kenya, 1987, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.60 |
| Reference: | 10.1016/j.cell.2015.01.041 |
| Antibody | |
| Antibody: | MR78 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Marburg virus GP1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: P
Mutation: NULL
| >5UQY_P|Chain D, H, L, P|MR78 Fab heavy chain|Homo sapiens (9606) QLQLQESGPGLVKPSETLSLTCTVSGGSISSSSYYWGWIRQPPGKGLEWIGSVYYSGGASYNPSLKSRATISVDTSKNQFSLNLDSVSAADTAIYYCASIYGSGTFYYYFYMDVWGKGSTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: O
Mutation: NULL
| >5UQY_O|Chain C, G, K, O|MR78 Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCQASQVISNYLNWYQQKPGKAPKLLIYDTSNLKTGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYENLQFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLRSPVTKSFNR |
Antigen
Chain: M
Mutation: NULL
| >5UQY_M|Chain A, E, I, M|ENVELOPE GLYCOPROTEIN GP1|Lake Victoria marburgvirus (strain Ravn-87) (378809) KTLPVLEIASNSQPQDVDSVCSGTLQKTEDVHLMGFTLSGQKVADSPLEASKRWAFRTGVPPKNVEYTEGEEAKTCYNISVTDPSGKSLLLDPPSNIRDYPKCKTVHHIQGQNPHAQGIALHLWGAFFLYDRVASTTMYRGKVFTEGNIAAMIVNKTVHRMIFSRQGQGYRHMNLTSTNKYWTSSNETQRNDTGCFGILQEYNSTNNQTCPPSLKPPSLPTVTPSIHSTNTQINTAKSGTRPPIYFRKKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| O: GLN27 VAL28 ILE29 SER30 ASN31 TYR32 ASP50 THR51 SER67 GLY68 TYR91 GLU92 ASN93 LEU94 P: SER32 TYR35 TYR54 SER56 GLY58 ALA59 SER60 GLY104 THR105 PHE106 TYR107 TYR108 TYR109 PHE110 M: SER62 PRO63 LEU64 SER67 LYS68 TRP70 ALA71 PHE72 ILE95 VAL97 THR98 PRO100 SER101 LEU106 HIS123 HIS124 ILE125 GLN126 GLY127 GLN128 ASN129 PRO130 HIS131 ALA136 LEU139 MET154 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
