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Entry information

Complex
AACDB_ID: 1772
PDBID: 5UMN
Chains: CD_B
Organism: Influenza A virus (A/Hong Kong/1/1968(H3N2)), Homo sapiens
Method: XRD
Resolution (Å): 1.97
Reference: 10.1038/ncomms15371
Antibody
Antibody: C05 Fab
Antibody mutation: Yes
INN (Clinical Trial):
Antigen
Antigen: Influenza A virus H3N2 hemagglutinin
Antigen mutation: No
Durg Target: P03437

Sequence information

Antibody

Heavy Chain: C
Mutation: V111P/S112G/A113S

>5UMN_C|Chain C, E|Antibody C05 VPGSGW mutant, heavy chain|Homo sapiens (9606)
QVQLQESGGGLVQPGESLRLSCVGSGSSFGESTLSYYAVSWVRQAPGKGLEWLSIINAGGGDIDYADSVEGRFTISRDNSKETLYLQMTNLRVEDTGVYYCAKHMSMQQVPGSGWERADLVGDAFDVWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH

Light Chain: D
Mutation: NULL

>5UMN_D|Chain D, F|Antibody C05, light chain|Homo sapiens (9606)
DIQLTQSPSSLSASVGDRVTLTCQASQDIRKFLNWYQQKPGKGPKLLIYDASNLQRGVPSRFSGGGSGTDFTLIISSLQPEDVGTYYCQQYDGLPFTFGGGTKVVIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Antigen

Chain: B
Mutation: NULL

>5UMN_B|Chain A, B|Hemagglutinin|Influenza A virus (506350)
VQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVGHHHHHH

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

C: TYR31 MET98

B: TYR98 THR131 GLN132 ASN133 GLY134 GLY135 SER136 ASN137 SER145 TRP153 THR155 LYS156 SER157 GLY158 HIS183 GLN189 GLU190 THR192 SER193 LEU194 TRP222 GLY225 LEU226 SER227 SER228

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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