Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1759 |
| PDBID: | 5UK4 |
| Chains: | r_R |
| Organism: | Vesicular stomatitis Indiana virus strain San Juan, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.15252/embr.201643764 |
| Antibody | |
| Antibody: | 1307 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Vesicular stomatitis virus N protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: r
Mutation: NULL
| >5UK4_R|Chain A, AA[auth B], C, CA[auth D], E, EA[auth F], G, GA[auth H], I, IA[auth J], K, KA[auth L], M, MA[auth N], O, Q[auth P], S[auth Q], U[auth R], W[auth S], Y[auth T]|Nucleoprotein|Vesicular stomatitis Indiana virus (strain San Juan) (11285) MSVTVKRIIDNTVIVPKLPANEDPVEYPADYFRKSKEIPLYINTTKSLSDLRGYVYQGLKSGNVSIIHVNSYLYGALKDIRGKLDKDWSSFGINIGKAGDTIGIFDLVSLKALDGVLPDGVSDASRTSADDKWLPLYLLGLYRVGRTQMPEYRKKLMDGLTNQCKMINEQFEPLVPEGRDIFDVWGNDSNYTKIVAAVDMFFHMFKKHECASFRYGTIVSRFKDCAALATFGHLCKITGMSTEDVTTWILNREVADEMVQMMLPGQEIDKADSYMPYLIDFGLSSKSPYSSVKNPAFHFWGQLTALLLRSTRARNARQPDDIEYTSLTTAGLLYAYAVGSSADLAQQFCVGDNKYTPDDSTGGLTTNAPPQGRDVVEWLGWFEDQNRKPTPDMMQYAKRAVMSLQGLREKTIGKYAKSEFDK |
Antigen
Chain: R
Mutation: NULL
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| r: LYS23 ARG27 THR28 SER30 ASN31 TRP53 ARG54 ASP56 ARG72 ASN74 ALA75 ASN77 LYS100 ALA101 TYR102 ASN103 R: ASP359 SER360 THR361 GLY362 LEU364 THR365 THR366 ASN367 ALA368 PRO370 GLN371 ASP374 VAL376 GLU377 GLY380 TRP381 ASP384 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
