Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1726 |
| PDBID: | 5UG0 |
| Chains: | DC_A |
| Organism: | Influenza A virus (A/Solomon Islands/3/2006(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.40 |
| Reference: | 10.1016/j.jmb.2017.05.011 |
| Antibody | |
| Antibody: | 2897 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >5UG0_D|Chain D|2897 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFNIYDMHWVRQAPGKGLEWVSSITTAGDTYYPGSVKGRFTTSRENAKNSLYLQMNSLRAGDTGVYYCTRGVREVGATGDDPFYYGMYVWGQGTTVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: C
Mutation: NULL
| >5UG0_C|Chain C|2897 light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGEKATLSCRASQSVSSYYLGWYQQKPGQAPRLLIYETSRRATGIPDRFSGSGSGTDFTLTISGLEPEDFAVYYCQHYGVSPVITFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5UG0_A|Chain A|Hemagglutinin HA1|Influenza A virus (A/Solomon Islands/3/2006(H1N1)) (464623) EDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHTENAYVSVVSSHYSRKFTPEIAKRPKVRDREGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGFGSGIINSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: SER30 TYR32 TYR33 VAL94 D: THR28 ASN30 ILE31 THR53 ALA54 GLY55 TYR58 ARG71 ASN73 ARG100 GLU101 VAL102 GLY103 ALA104 THR105 GLY106 ASP107 PHE110 A: TYR95 THR131 THR133 GLY134 VAL135 SER136 ALA137 GLY143 GLU144 SER145 TRP153 THR155 LYS157 ASN158 GLY159 PRO186 ASN187 ASP190 ARG192 ALA193 LEU194 HIS196 LYS222 ASP225 ARG226 GLU227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
