Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1715 |
| PDBID: | 5UDC |
| Chains: | HL_F |
| Organism: | Homo sapiens, Human respiratory syncytial virus A2 |
| Method: | XRD |
| Resolution (Å): | 3.45 |
| Reference: | 10.1126/scitranslmed.aaj1928 |
| Antibody | |
| Antibody: | MEDI8897 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Nirsevimab(Approved) |
| Antigen | |
| Antigen: | Fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5UDC_H|Chain A[auth B], D[auth E], G[auth H]|MEDI8897 Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVMVSCQASGGLLEDYIINWVRQAPGQGPEWMGGIIPVLGTVHYGPKFQGRVTITADESTDTAYMELSSLRSEDTAMYYCATETALVVSETYLPHYFDNWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKS |
Light Chain: L
Mutation: NULL
| >5UDC_L|Chain B[auth C], E[auth G], H[auth L]|MEDI8897 Fab Light Chain|Homo sapiens (9606) DIQMTQSPSSLSAAVGDRVTITCQASQDIVNYLNWYQQKPGKAPKLLIYVASNLETGVPSRFSGSGSGTDFSLTISSLQPEDVATYYCQQYDNLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >5UDC_F|Chain C[auth A], F[auth D], I[auth F]|Fusion glycoprotein F0|Human respiratory syncytial virus A (strain A2) (11259) MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGGLVPRGSHHHHHHSAWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP31 VAL53 LEU54 THR96 LEU98 VAL99 ASP101 L: VAL30 ASN31 TYR32 LEU46 TYR49 VAL50 ASN53 GLU55 THR56 TYR91 ASP92 F: SER62 ASN63 ILE64 LYS65 GLU66 ASN67 LYS68 CYS69 LEU83 LYS196 ASN197 TYR198 ASP200 LYS201 GLN202 LEU204 PRO205 ILE206 LEU207 ASN208 LYS209 GLN210 SER211 CYS212 ASN216 THR219 GLU295 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
