Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1711 |
| PDBID: | 5U68 |
| Chains: | F_B |
| Organism: | Human respiratory syncytial virus A2, Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.08 |
| Reference: | 10.1038/nmicrobiol.2016.272 |
| Antibody | |
| Antibody: | MPE8 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | respiratory syncytial virus F protein |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; |
Sequence information
Antibody
Chain: F
Mutation: NULL
| >5U68_F|Chain D[auth E], E[auth F], F[auth G]|MPE8|Homo sapiens (9606) MELGLRWVFLVAILEGVQCEVQLVESGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYYADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARARATGYNSITPYFDIWGQGTLVTVSSGTGGSGGGGSGGGGSGGGASQSVVTQTPSVSGAPGQRVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYDNNNRPSGVPDRFSASKSGTSASLAITGLQAEDEADYYCQSYDRSLSGVFGTGTKVTVLGSGENLYFQSGGSGGHHHHHH |
Antigen
Chain: B
Mutation: NULL
| >5U68_B|Chain A, B, C|Chimera protein of Fusion glycoprotein F0 and Envelope glycoprotein|Human respiratory syncytial virus A (strain A2) (11259) MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGGLVPRGSSAHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: THR47 SER49 SER50 TYR51 SER52 SER69 SER71 SER72 SER73 SER75 TYR76 TYR78 ARG119 ALA120 THR121 GLY122 TYR123 ASN124 SER125 ILE126 PRO128 GLY193 ALA194 GLY195 TYR196 GLY233 TYR256 ARG258 SER261 B: LEU45 THR50 GLY51 TRP52 TYR53 THR54 SER150 VAL154 VAL178 SER180 VAL185 SER186 ASN262 ASP263 MET264 PRO265 ILE266 THR267 ASN268 ASP269 GLN270 LYS271 LYS272 LEU273 LEU305 TYR306 GLY307 ILE309 ASP310 THR311 PRO312 ASP344 ASN345 ALA346 GLY347 ARG364 SER377 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
