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Entry information

Complex
AACDB_ID: 171
PDBID: 1TZI
Chains: BA_V
Organism: Mus musculus, Homo sapiens
Method: XRD
Resolution (Å): 2.80
Reference: 10.1073/pnas.0401786101
Antibody
Antibody: YADS2 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Vascular endothelial growth factor A
Antigen mutation: No
Durg Target: P15692

Sequence information

Antibody

Heavy Chain: B
Mutation: NULL

>1TZI_B|Chain B|Fab YADS2 Heavy Chain|Mus musculus (10090)
EVQLVESGGGLVQPGGSLRLSCAASGFAIYDYDIHWVRQAPGKGLEWVADIAPYAGATAYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRSSYAYYAAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS

Light Chain: A
Mutation: NULL

>1TZI_A|Chain A|Fab YADS2 Light Chain|Mus musculus (10090)
DIQMTQSPSSLSASVGDRVTITCRASQSYAYAVAWYQQKPGKAPKLLIYDASYLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQAYSSPDTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Antigen

Chain: V
Mutation: NULL

>1TZI_V|Chain C[auth V]|Vascular endothelial growth factor A|Homo sapiens (9606)
GQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKD

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

A: TYR29 TYR92

B: TYR30 TYR53 ALA54 GLY55 TYR97

V: LYS16 PHE17 MET18 TYR21 ASP63 GLY65 LEU66 ARG105 PRO106

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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