Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1702 |
| PDBID: | 5TSJ |
| Chains: | 1_H |
| Organism: | Thermus thermophilus HB8, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 8.70 |
| Reference: | 10.1016/j.jsb.2017.01.002 |
| Antibody | |
| Antibody: | 5TSJ VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | V-type ATP synthase subunit E |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: 1
Mutation: NULL
| >5TSJ_1|Chain AA[auth 1], BA[auth 2]|Human heavy chain domain antibody|Homo sapiens (9606) STEVQLLESGGGLVQPGGSLRLSCAASGFTFSTYMMSWVRQAPGKGLEWVSSIEGSGSKTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKRDSSFGFDYWGQGTLVTVSSAAALEIKRASQPELAPEDPEDVEHHHHHH |
Antigen
Chain: H
Mutation: NULL
| >5TSJ_H|Chain G, H|V-type ATP synthase subunit E|Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (300852) KLEAILSQEVEAEIQALLQEAEAKAEAVKREAEEKAKALLQARERALEAQYRAALRRAESAGELLVATARTQARGEVLEEVRRRVREALEALPQKPEWPEVVRKLALEALEALPGAKALVANPEDLPHLEAMARERGVELQAEPALRLGVRAVGAEGKTQVENSLLARMDRAWDAMSSKVAQALWG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| 1: SER50 THR58 TYR59 TYR60 SER102 PHE103 H: ALA90 ALA93 GLN96 LYS97 PRO98 GLU99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
