Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1699 |
| PDBID: | 5TPN |
| Chains: | HL_A |
| Organism: | Human respiratory syncytial virus A2, Enterobacteria phage Ox2, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.14 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | hRSV90 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Fusion glycoprotein F0 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5TPN_H|Chain B[auth H]|hRSV90 heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPRRSLRLSCAASGFTFDDYTIHWVRQAPGKGLEWVSGITWNSGYIGYADSVKGRFTISRDNARNSLYLQMNSLRAEDTALYYCVRDAYVSGSDYYYYGLDVWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: L
Mutation: NULL
| >5TPN_L|Chain C[auth L]|hRSV0 light chain|Homo sapiens (9606) EIVMTSSPATLSVSPGERVTLFCRASQSVISNLAWYQQKSGQAPRLLIYGASTRATGIPSRFSGSGSGTEFTLTISSLQSEDFAVYFCQQYNNWPLTFGGGTQVNVQRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >5TPN_A|Chain A|Fusion glycoprotein F0,Fibritin|Human respiratory syncytial virus A (11259) NITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKKIKCNGTDAKIKLIKQELDKYKNAVTELQLLMQSTPATNNQARGSGSGRSLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDQFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGGLVPRGSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP36 THR38 THR57 TRP58 ASN59 TYR64 ASP107 TYR109 VAL110 SER111 TYR113 L: GLN27 SER28 ILE36 SER37 ASN38 SER83 TYR107 ASN108 ASN109 TRP110 A: LYS166 SER169 ALA170 LEU171 LEU172 SER173 THR174 ASN175 LYS176 ALA177 VAL178 SER180 LEU188 LYS191 VAL192 ASP194 LYS196 ASN197 ASP200 LYS201 LYS226 ASN262 ASP263 PRO265 LYS271 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
