Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1685 |
| PDBID: | 5TJW |
| Chains: | K_A |
| Organism: | Influenza A virus (A/WSN/1933(H1N1)), Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 3.23 |
| Reference: | 10.1128/mBio.01569-16 |
| Antibody | |
| Antibody: | αNP VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Nucleoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: K
Mutation: NULL
| >5TJW_K|Chain B[auth K]|NP-specific inhibitory VHH|Vicugna pacos (30538) QVQLQESGGGLVQAGGSLRLTCALSERTSTSYAQGWFRQPPGKEREFVASLRTHDGNTHYTDSVKGRFTISRDNAENTLYLQMNSLKTEDTAVYYCAASLGYSGAYASGYDYWGQGTQVTVSSGGLPETGGHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >5TJW_A|Chain A|Nucleoprotein|Influenza A virus (A/WSN/1933(H1N1)) (382835) MATKGTKRSYEQMETDGERQNATEIRASVGKMIDGIGRFYIQMCTELKLSDYEGRLIQNSLTIERMVLSAFDERRNKYLEEHPSAGKDPKKTGGPIYRRVDGKWRRELILYDKEEIRRIWRQANNGDDATAGLTHMMIWHSNLNDATYQRTRALVRTGMDPRMCSLMQGSTLPRRSGAAGAAVKGVGTMVMELIRMIKRGINDRNFWRGENGRRTRIAYERMCNILKGKFQTAAQRTMVDQVRESRNPGNAEFEDLIFLARSALILRGSVAHKSCLPACVYGSAVASGYDFEREGYSLVGIDPFRLLQNSQVYSLIRPNENPAHKSQLVWMACHSAAFEDLRVSSFIRGTKVVPRGKLSTRGVQIASNENMETMESSTLELRSRYWAIRTRSGGNTNQQRASSGQISIQPTFSVQRNLPFDRPTIMAAFTGNTEGRTSDMRTEIIRLMESARPEDVSFQGRGVFELSDEKATSPIVPSFDMSNEGSYFFGDNAEEYDNGLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: TYR33 ARG53 HIS55 ASP56 LEU101 GLY102 TYR103 SER104 TYR107 SER109 GLY110 ASP112 A: TYR52 ARG99 ASP101 GLY102 LYS103 TRP104 GLN311 TYR313 ILE316 PRO318 ASN319 GLU320 ASN321 PRO322 ALA323 SER359 GLU372 MET374 GLU375 SER376 SER377 THR378 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
