Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1646 |
| PDBID: | 5SV3 |
| Chains: | C_D |
| Organism: | Lama glama, Ricinus communis |
| Method: | XRD |
| Resolution (Å): | 2.73 |
| Reference: | 10.1080/19420862.2016.1236882 |
| Antibody | |
| Antibody: | A3C8 VH-sdAb |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ricin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >5SV3_C|Chain A, C|Anti-Ricin A-chain Single Domain Antibody (sdAb) A3C8|Lama glama (9844) MAEVQLVESGGGLVQAGDSLRLSCTASGRTLGDYGVAWFRQAPGKEREFVSVISRSTIITDYADSVRGRFSISADSAKNTVYLQMNSLKPEDTAVYYCAVIANPVYATSRNSDDYGHWGQGTQVTVSSAAALEHHHHHH |
Antigen
Chain: D
Mutation: NULL
| >5SV3_D|Chain B, D|Ricin|Ricinus communis (3988) MAIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER54 ILE56 ILE57 THR58 ASP59 ASP62 ARG65 PRO102 VAL103 TYR104 ALA105 THR106 SER107 ARG108 ASN109 ASP112 D: TYR91 HIS94 PRO95 ASP96 ASN97 GLN98 ALA101 ILE104 THR105 THR109 ASP110 VAL111 GLN112 ASN113 ARG114 TYR115 THR116 PHE117 ALA118 PHE119 TYR154 LEU161 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
