Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1633 |
| PDBID: | 5O6V |
| Chains: | IM_C |
| Organism: | Tick-borne encephalitis virus (strain HYPR), Mus musculus |
| Method: | EM |
| Resolution (Å): | 3.90 |
| Reference: | 10.1038/s41467-018-02882-0 |
| Antibody | |
| Antibody: | 19/1786 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tick-borne encephalitis virus Envelope protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >5O6V_I|Chain G[auth H], H[auth I]|Fab 19/1786 - Heavy chain|Mus musculus (10090) EVKLEESGGGLVQPGGSLKLSCAASGFTFSSYGMSWVRQTPDKRLELVAATNSDGDSTYYPDSVKGRFTISRDRAKNTLYLQMSSLKSEDTAMYYCTRVLYDYDGEFAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSKTWPSETVTCNVAHPASSTK |
Light Chain: M
Mutation: NULL
| >5O6V_M|Chain I[auth L], J[auth M]|Fab 19/1786 - Light chain|Mus musculus (10090) DIVMTQSQKFMSTSVGDRVTVTCKASQNVGTNVAWYQQKPGQSPKGLIYSASYRYSGVPDRFIGSGSGTDFTLTISNVQSGDLAEYFCQQYNNHPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQDGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKS |
Antigen
Chain: C
Mutation: NULL
| >5O6V_C|Chain A, B, C|Envelope protein|Tick-borne encephalitis virus (strain Hypr) (70733) SRCTHLENRDFVTGTQGTTRVTLVLELGGCVTITAEGKPSMDVWLDAIYQENPAQTREYCLHAKLSDTKVAARCPTMGPATLAEEHQGGTVCKRDQSDRGWGNHCGLFGKGSIVACVKAACEAKKKATGHVYDANKIVYTVKVEPHTGDYVAANETHSGRKTASFTVSSEKTILTMGEYGDVSLLCRVASGVDLAQTVILELDKTVEHLPTAWQVHRDWFNDLALPWKHEGARNWNNAERLVEFGAPHAVKMDVYNLGDQTGVLLKALAGVPVAHIEGTKYHLKSGHVTCEVGLEKLKMKGLTYTMCDKTKFTWKRAPTDSGHDTVVMEVTFSGTKPCRIPVRAVAHGSPDVNVAMLITPNPTIENNGGGFIEMQLPPGDNIIYVGELSYQWFQKGSSIGRVFQKTKKGIERLTVIGEHAWDFGSAGGFLSSIGKALHTVLGGAFNSIFGGVGFLPKLLLGVALAWLGLNMRNPTMSMSFLLAGVLVLAMTLGVGA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: SER30 SER31 ASN52 SER53 ASP54 ASP56 SER57 THR58 TYR59 LYS65 TYR101 ASP102 TYR103 ASP104 GLY105 M: ILE2 GLN27 THR31 ASN32 TYR91 ASN92 ASN93 HIS94 LEU96 C: THR303 TYR304 THR305 MET306 CYS307 ASP308 LYS309 THR310 LYS311 SER333 GLY334 THR335 LYS336 PRO337 ARG339 ASN366 GLU387 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
