Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1627 |
| PDBID: | 5O1R |
| Chains: | IM_B |
| Organism: | Neisseria meningitidis, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.86 |
| Reference: | 10.1371/journal.pone.0201922 |
| Antibody | |
| Antibody: | 5H2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | GNA2132 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >5O1R_I|Chain C[auth H], D[auth I]|IGH@ protein|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGSSYWTWIRQTPGKGLEWIGYTSYSGSTKYNPSLKSRVTLSVDMSKNQFSLKLKSVTAADTAVYFCARDRFDVASGSSFDFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGSENLYFQGSWSHPQFEKGGSGGGSGGGSWSHPQFEK |
Light Chain: M
Mutation: NULL
| >5O1R_M|Chain E[auth L], F[auth M]|Uncharacterized protein|Homo sapiens (9606) EIVMTQTPSSLSASVGDRVTITCRASQSISNYLNWYQQKPGTAPKLLTYAASSLGSGVPSRFSGSGSGTDLTLTISSLRPEDFATYYCQQSYGSPTFGQGTKLEIRRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >5O1R_B|Chain A, B|GNA2132|Neisseria meningitidis (487) MASMLAGTAVYNGEVLHFHTENGRPYPTRGRFAAKVDFGSKSVDGIIDSGDDLHMGTQKFKAAIDGNGFKGTWTENGGGDVSGRFYGPAGEEVAGKYSYRPTDAEKGGFGVFAGKKEQDLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: SER30 SER31 GLY32 SER33 TYR35 TYR52 SER56 SER58 THR59 LYS60 ASP100 PHE102 ASP103 VAL104 ALA105 SER106 GLY107 SER108 M: GLU1 ILE2 GLN27 SER30 ASN31 TYR32 SER91 TYR92 GLY93 SER94 PRO95 B: VAL318 ASN320 GLY321 GLU322 ARG337 GLY338 ARG339 PHE340 ALA341 ALA342 LYS343 ASP352 GLY353 ILE354 ASP356 GLY358 ASP360 LEU361 MET363 GLY364 THR365 GLN366 LYS367 GLU383 LYS423 GLU425 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
