Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1618 |
| PDBID: | 5NUZ |
| Chains: | HL_D |
| Organism: | Mus musculus, Mammarenavirus juninense |
| Method: | XRD |
| Resolution (Å): | 1.85 |
| Reference: | 10.1073/pnas.1702127114 |
| Antibody | |
| Antibody: | eOD01 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Junin virus GP1 glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5NUZ_H|Chain A, B[auth H]|eOD01 heavy chain|Mus musculus (10090) ETGEVQLQQSGTVLARPGASVKMSCKASGYTFTSYWMHWIKQRPGQGLEWIGAIYPGDSDTKYNQKFKGKAKLTAVTSTSTAYMELSSLTNEDSAVYYCTRRNTLTGDYFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCHHHHHH |
Light Chain: L
Mutation: NULL
| >5NUZ_L|Chain C[auth B], E[auth L]|eOD01 light chain|Mus musculus (10090) ETGDIVLTQSPASLAVSLGQRATISCRASESVDDYGISFMNWFQQKPGQPPKLLIYTASSQGSGVPARFSGSGSGTDFSLNIHPMEEDDTAMYFCQQSKEVPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: D
Mutation: NULL
| >5NUZ_D|Chain D[auth C], F[auth D]|Pre-glycoprotein polyprotein GP complex|Junin mammarenavirus (2169991) ETGDLPLLCTLNKSHLYIKGGNASFQISFDDIAVLLPQYDVIIQHPADMSWCSKSDDQIWLSQWFMNAVGHDWHLDPPFLCRNRTKTEGFIFQVNTSKTGVNENYAKKFKTGMHHLYREYPDSCLNGKLCLMKAQPTSWPLQCPLDHVNKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TRP33 ASP54 ASP56 ARG95 THR97 LEU98 THR99 L: ILE30 PHE32 D: SER111 ASP113 ASP114 ILE115 ALA116 VAL117 LEU119 GLN121 TYR122 ARG165 GLU171 ILE174 LEU208 ASN209 GLY210 LYS211 LEU212 LYS216 GLN218 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
