Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 161 |
| PDBID: | 1SQ2 |
| Chains: | N_L |
| Organism: | Gallus gallus, Ginglymostoma cirratum |
| Method: | XRD |
| Resolution (Å): | 1.45 |
| Reference: | 10.1126/science.1101148 |
| Antibody | |
| Antibody: | 1SQ2 IgNARs |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: N
Mutation: NULL
| >1SQ2_N|Chain B[auth N]|novel antigen receptor|Ginglymostoma cirratum (7801) ARVDQTPRSVTKETGESLTINCVLRDASYALGSTCWYRKKSGEGNEESISKGGRYVETVNSGSKSFSLRINDLTVEDGGTYRCGLGVAGGYCDYALCSSRYAECGDGTAVTVN |
Antigen
Chain: L
Mutation: NULL
| >1SQ2_L|Chain A[auth L]|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| N: SER28 TYR29 ALA30 GLY32 SER33 LEU85 GLY86 VAL87 ALA88 GLY89 TYR91 ASP93 ALA95 LEU96 SER99 ARG100 TYR101 ALA102 GLU103 L: ARG21 TYR23 ASN46 ASP52 GLN57 ILE58 ASN59 ARG61 TRP62 TRP63 ARG73 LEU75 LYS97 ILE98 ASP101 GLY102 ASN103 GLY104 ASN106 ALA107 TRP108 VAL109 TRP111 ARG112 LYS116 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
