Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 16 |
| PDBID: | 1BZQ |
| Chains: | K_D |
| Organism: | Bos taurus, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1016/s0969-2126(99)80049-5 |
| Antibody | |
| Antibody: | cAb-Lys3 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | RNASE A |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: K
Mutation: NULL
| >1BZQ_K|Chain E[auth K], F[auth L], G[auth M], H[auth N]|PROTEIN (ANTIBODY CAB-RN05)|Camelus dromedarius (9838) QVQLVESGGGLVQAGGSLRLSCAASGYAYTYIYMGWFRQAPGKEREGVAAMDSGGGGTLYADSVKGRFTISRDKGKNTVYLQMDSLKPEDTATYYCAAGGYELRDRTYGQWGQGTQVTVSSRGR |
Antigen
Chain: D
Mutation: NULL
| >1BZQ_D|Chain A, B, C, D|PROTEIN (RNASE A)|Bos taurus (9913) KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: VAL802 TYR827 ALA828 TYR829 THR830 TYR831 ILE832 TYR833 GLY899 GLY900 TYR901 ARG904 ARG906 THR907 TYR908 GLY909 GLN910 D: SER659 GLN660 LYS661 ASN662 VAL663 ALA664 GLY668 GLN669 THR670 ASN671 TYR673 TYR676 GLU711 GLY712 TYR715 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
