Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1596 |
| PDBID: | 5N88 |
| Chains: | A_D |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.70 |
| Reference: | 10.1038/s41598-017-16742-2 |
| Antibody | |
| Antibody: | VH59 VH-sdAb |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | PC4 and SFRS1-interacting protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >5N88_A|Chain A, C[auth H]|VH59 antibody|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSTFSMNWVRQAPGKGLEWVSYISRTSKTIYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGGWALGDEIPSSFLEFDYWGQGTLVTVS |
Antigen
Chain: D
Mutation: NULL
| >5N88_D|Chain B[auth D]|PC4 and SFRS1-interacting protein|Homo sapiens (9606) SMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: GLN39 GLY44 LEU45 TRP47 TYR95 ARG98 TRP101 PRO108 SER109 SER110 PHE111 LEU112 GLU113 PHE114 ASP115 TYR116 TRP117 D: LYS360 LEU363 LYS364 ILE365 LEU368 VAL370 THR399 LYS402 ILE403 ARG405 PHE406 LYS407 VAL408 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
