Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1594 |
| PDBID: | 5N7W |
| Chains: | AB_X |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.96 |
| Reference: | 10.1016/j.celrep.2018.10.081 |
| Antibody | |
| Antibody: | h142 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-17A |
| Antigen mutation: | No |
| Durg Target: | Q16552 |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >5N7W_A|Chain A, C[auth H]|Antibody Fragment Heavy Chain|Homo sapiens (9606) QVKLVQSGAEVKKPGASVKVSCKASGYTFSSYWIAWVRQAPGQGLEWIGEILPGSGSTNYAQKFQGRATMTADTSTSTVYMELSSLRSEDTAVYYCARFPYYYGNWDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: B
Mutation: NULL
| >5N7W_B|Chain B, D[auth L]|Antibody Fragment Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCQASQDIWWYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGSGTDYTFTISSLQPEDIATYYCQQGFYLPWTFGGGTKVEIKLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: X
Mutation: NULL
| >5N7W_X|Chain E[auth X], F[auth Y]|Interleukin-17A|Homo sapiens (9606) MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: TRP33 ASN59 TYR101 TYR102 B: ASP28 TRP30 TYR32 GLY91 PHE92 TYR93 LEU94 TRP96 X: ASP15 LYS16 ASN17 PHE18 ARG20 THR21 VAL22 LEU112 LYS114 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
