Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1552 |
| PDBID: | 5LJY |
| Chains: | HL_A |
| Organism: | Hantaan virus 76-118, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1371/journal.ppat.1005813 |
| Antibody | |
| Antibody: | A5 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Envelopment polyprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5LJY_H|Chain B[auth H], C[auth L]|scFvA5|Homo sapiens (9606) SLGAMAQVQLQESGPGLVKPSETLSLTCVVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSPNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARQMRQWGQGTLVTVSSGGGGSGGGGSGGSALSSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSRDSSGNHNVFGGGTKLTVLGAAADDDDKAGWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Light Chain: L
Mutation: NULL
| >5LJY_L|Chain B[auth H], C[auth L]|scFvA5|Homo sapiens (9606) SLGAMAQVQLQESGPGLVKPSETLSLTCVVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSPNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARQMRQWGQGTLVTVSSGGGGSGGGGSGGSALSSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSRDSSGNHNVFGGGTKLTVLGAAADDDDKAGWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Antigen
Chain: A
Mutation: NULL
| >5LJY_A|Chain A|Envelopment polyprotein|Hantaan virus (strain 76-118) (11602) SETPLTPVWNDNAHGVGSVPMHTDLELDFSLTSSSKYTYRRKLTNPLEEAQSIDLHIEIEEQTIGVDVHALGHWFDGRLNLKTSFHCYGACTKYEYPWHTAKCHYERDYQYETSWGCNPSDCPGVGTGCTACGLYLDQLKPVGSAYKIITIRYSRRVCVQFGEENLCKIIDMNDCFVSRHVKVCIIGTVSKFSQGDTLLFFGPLEGGGLIFKHWCTSTCQFGDPGDIMSPRDKGFLCPEFPGSFRKKCNFATTPICEYDGNMVSGYKKVMATIDSFQSFNTSTMHFTDERIEWKDPDGMLRDHINILVTKDIDFDNLGENPCKIGLQTSSIEGAWGSGVGFTLTCLVSLTECPTFLTSIKACDKAICYGAESVTLTRGQNTVKVSGKGGHSGSTFRCCHGEDCSQIGLHAAAPHLDKVNGISEIENSKVYDDGAPQCGIKCWFVKSGEWISGIFSGNGGSDDDDKAGWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER30 SER31 ASN33 TRP34 GLU50 TYR52 HIS53 SER54 GLY55 GLN95 ARG101 L: LEU28 ARG29 SER30 TYR31 TYR32 SER34 TYR49 GLY50 LYS51 SER66 SER67 GLY68 ARG91 SER93 SER94 A: PHE75 ARG78 LYS82 THR83 SER84 PHE85 HIS86 LYS93 TYR94 GLU95 TYR96 PRO97 TRP98 HIS99 THR100 ALA101 LYS102 TYR135 LEU136 ASP137 GLN138 LEU139 LYS140 PRO141 ASP232 LYS233 GLY234 PHE235 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
