Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 155 |
| PDBID: | 1RVF |
| Chains: | HL_1 |
| Organism: | rhinovirus B14, Human rhinovirus sp., Mus musculus |
| Method: | XRD |
| Resolution (Å): | 4.00 |
| Reference: | 10.1038/383350a0 |
| Antibody | |
| Antibody: | 17-IA Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HUMAN RHINOVIRUS 14 COAT PROTEIN |
| Antigen mutation: | No |
| Durg Target: | P03303 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1RVF_H|Chain F[auth H]|FAB 17-IA|Mus musculus (10090) QGQLQQSGAELVRPGSSVKISCKASGYAFSSFWVNWVKQRPGQGLEWIGQIYPGDGDNKYNGKFKGKATLTADKSSTTAYMQLYSLTSEDSAVYFCARSGNYPYAMDYWGQGTSVTVSS |
Light Chain: L
Mutation: NULL
| >1RVF_L|Chain E[auth L]|FAB 17-IA|Mus musculus (10090) QIVLTQSPAIMSAFPGEKVTITCSATSSVNYMHWFQQKPGTSPKLWIYSSSNLASGVPARFSGSGSGTSYSLTISRMEAEDAATYYCQQRSSYPITFGSGTKLEIKRADA |
Antigen
Chain: 1
Mutation: NULL
| >1RVF_1|Chain A[auth 1]|HUMAN RHINOVIRUS 14 COAT PROTEIN|Human rhinovirus 14 (12131) GLGDELEEVIVEKTKQTVASISSGPKHTQKVPILTANETGATMPVLPSDSIETRTTYMHFNGSETDVECFLGRAACVHVTEIQNKDATGIDNHREAKLFNDWKINLSSLVQLRKKLELFTYVRFDSEYTILATASQPDSANYSSNLVVQAMYVPPGAPNPKEWDDYTWQSASNPSVFFKVGDTSRFSVPYVGLASAYNCFYDGYSHDDAETQYGITVLNHMGSMAFRIVNEHDEHKTLVKIRVYHRAKHVEAWIPRAPRALPYTSIGRTNYPKNTEPVIKKRKGDIKSY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR32 HIS34 ARG91 SER92 TYR94 ILE96 H: SER17 TRP33 GLN50 GLY53 ASP54 ASP56 ASN57 LYS58 LYS64 GLY65 GLN81 SER95 TYR98 PRO99 1: VAL79 THR80 GLU81 GLN83 LYS85 GLY89 ILE90 ASP91 ASN92 ARG94 GLU95 ALA96 LYS97 ASN100 ASP101 LYS161 GLN212 LEU238 LYS240 ARG268 LYS273 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
