Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1534 |
| PDBID: | 5KVG |
| Chains: | HL_E |
| Organism: | Zika virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.40 |
| Reference: | 10.1016/j.cell.2016.07.020 |
| Antibody | |
| Antibody: | ZV-67 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika envelope DIII |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5KVG_H|Chain C[auth H]|ZV-67 Antibody Fab Heavy Chain|Mus musculus (10090) EAQLQQSGTGLARPGASVKLSCKASGYTFTSYGISWVTQRAGQGLEWIGVIYPRSGNTYYNEKFRGKATLTADKSSSSAYMELRGLTAEDSAVYFCARENYGSVYWGQGTTLTVSSAKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSGLYTLSSSVTVTSNTWPSQTITCNVAHPASSTKVDKKIEPRVPI |
Light Chain: L
Mutation: NULL
| >5KVG_L|Chain B[auth L]|ZV-67 Antibody Fab Light Chain|Mus musculus (10090) DIVMTQSQKFMSTSVGDRVSITCKASQNVGTAVAWYQQKPGQSPKLLIYSASNRYTGVPDRFTGSGSGTDFTLTISNMQSEDLADYFCQQFSSYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: E
Mutation: NULL
| >5KVG_E|Chain A[auth E]|ZIKA Envelope DIII|Zika virus (64320) MRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: GLY30 THR31 ALA32 LEU46 TYR49 SER50 SER52 ASN53 TYR55 THR56 PHE91 SER92 TYR94 TYR96 H: THR30 SER31 TYR32 ARG53 SER54 ASN56 TYR58 GLU95 ASN96 TYR97 GLY98 VAL101 E: THR309 ALA310 ALA311 PHE312 THR313 PHE314 THR315 LYS316 GLN331 ALA333 GLY334 THR335 ASP336 GLY337 PRO338 SER368 THR369 GLU370 ASN371 GLU393 LYS394 LYS395 ILE396 THR397 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
