Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1533 |
| PDBID: | 5KVF |
| Chains: | HL_E |
| Organism: | Zika virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.40 |
| Reference: | 10.1016/j.cell.2016.07.020 |
| Antibody | |
| Antibody: | ZV-64 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika envelope DIII |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5KVF_H|Chain C[auth H]|ZV-64 Antibody Fab Heavy Chain|Mus musculus (10090) EVQLQQPGAELVKPGASVKLSCKASGYTFTSSWMHWVKQRPGQGLEWIGMIHPNSGSTNYNEKFKNKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARYYYDYDGMDYWGQGTSVTVSSAKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSGLYTLSSSVTVTSNTWPSQTITCNVAHPASSTKVDKKIEPRVP |
Light Chain: L
Mutation: NULL
| >5KVF_L|Chain B[auth L]|ZV-64 Antibody Fab Light Chain|Mus musculus (10090) DIVMSQSPSSLAVSVGEKVTMSCKSSQSLLYSSNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTISSVKAEDLAVYYCQQYYTYPYTFGGGTKLEINRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: E
Mutation: NULL
| >5KVF_E|Chain A[auth E]|Zika envelope DIII|Zika virus (64320) MRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: LYS30 TYR32 TRP50 TYR91 TYR92 THR93 TYR94 TYR96 H: SER31 SER32 TRP33 HIS35 MET50 SER54 SER56 ASN58 TYR95 TYR96 TYR97 ASP98 TYR99 E: LEU307 LYS340 VAL341 PRO342 ALA343 GLN344 VAL347 ASP348 MET349 GLN350 THR351 LEU352 THR353 PRO354 VAL355 LEU358 ASP384 TYR386 VAL391 GLY392 GLU393 LYS395 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
