Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 153 |
| PDBID: | 1RJC |
| Chains: | A_B |
| Organism: | Camelus dromedarius, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 1.40 |
| Reference: | 10.1074/jbc.M413011200 |
| Antibody | |
| Antibody: | cAb-Lys2 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >1RJC_A|Chain A|camelid heavy chain antibody|Camelus dromedarius (9838) EVQLQASGGGSVQAGQSLRLSCATSGATSSSNCMGWFRQAPGKEREGVAVIDTGRGNTAYADSVQGRLTISLDNAKNTLYLQMNSLKPEDTAMYYCAADTSTWYRGYCGTNPNYFSYWGQGTQVTVSSRGRHHHHHH |
Antigen
Chain: B
Mutation: NULL
| >1RJC_B|Chain B|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ARG45 VAL50 ASP52 ASN57 THR58 ALA59 TYR60 ASP62 GLN65 ASP99 THR100 TRP103 ARG105 GLY106 TYR107 CYS108 GLY109 THR110 ASN111 ASN113 TYR114 PHE115 SER116 B: PHE34 GLU35 ASN44 ARG45 ASN46 THR47 ASP48 SER50 ASP52 GLN57 ASN59 ARG61 TRP62 ASN103 ASN106 VAL109 ALA110 ARG112 ASN113 ARG114 LYS116 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
