Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 152 |
| PDBID: | 1RI8 |
| Chains: | A_B |
| Organism: | Camelus dromedarius, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 1.85 |
| Reference: | 10.1074/jbc.M413011200 |
| Antibody | |
| Antibody: | 1D2L19 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >1RI8_A|Chain A|camelid ANTIBODY HEAVY CHAIN|Camelus dromedarius (9838) DVQLVESGGGSVQAGGSLRLSCAVSGYKDRNYCMGWFRRAPGKEREGVAVIDSSGRTAYADSVKGRFTISRDVALDTAYLQMNSLKPEDTAMYYCAAGWSSLGSCGTNRNRYNYWGQGTQVTVSSRGRHHHHHH |
Antigen
Chain: B
Mutation: NULL
| >1RI8_B|Chain B|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLU44 VAL50 ASP52 ARG56 THR57 ALA58 TYR59 ALA60 ASP61 TRP99 SER101 SER104 CYS105 GLY106 THR107 ASN108 ARG109 ASN110 ARG111 TYR112 ASN113 B: LYS33 PHE34 GLU35 ASN37 ASN44 ARG45 ASN46 THR47 ASP48 ASP52 GLN57 VAL109 ALA110 ASN113 ARG114 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
