Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 15 |
| PDBID: | 1BZQ |
| Chains: | M_C |
| Organism: | Bos taurus, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1016/s0969-2126(99)80049-5 |
| Antibody | |
| Antibody: | cAb-Lys3 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | RNASE A |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: M
Mutation: NULL
| >1BZQ_M|Chain E[auth K], F[auth L], G[auth M], H[auth N]|PROTEIN (ANTIBODY CAB-RN05)|Camelus dromedarius (9838) QVQLVESGGGLVQAGGSLRLSCAASGYAYTYIYMGWFRQAPGKEREGVAAMDSGGGGTLYADSVKGRFTISRDKGKNTVYLQMDSLKPEDTATYYCAAGGYELRDRTYGQWGQGTQVTVSSRGR |
Antigen
Chain: C
Mutation: NULL
| >1BZQ_C|Chain A, B, C, D|PROTEIN (RNASE A)|Bos taurus (9913) KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: TYR1227 ALA1228 TYR1229 THR1230 TYR1231 ILE1232 TYR1233 GLY1299 GLY1300 TYR1301 ARG1304 ARG1306 THR1307 TYR1308 GLY1309 GLN1310 C: SER459 GLN460 LYS461 ASN462 VAL463 ALA464 GLY468 GLN469 THR470 ASN471 TYR473 TYR476 GLU511 GLY512 TYR515 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
