Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1493 |
| PDBID: | 5K9Q |
| Chains: | ST_N |
| Organism: | Influenza A virus (A/Hong Kong/1/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1016/j.cell.2016.06.043 |
| Antibody | |
| Antibody: | 16.a.26 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: S
Mutation: NULL
| >5K9Q_S|Chain G, H, J, S, U, W[auth X]|16.a.26 Heavy chain|Homo sapiens (9606) QVQLVQSGPEVKKPGASVKVSCKASGYSFSRYGISWVRQAPGQGLEWLGWISGYTGNTNYAQKFQGRVTMTTDTSTSTASMELRSLRSDDTAVYYCARDKKQGEVVLPAASFRWFAPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: T
Mutation: NULL
| >5K9Q_T|Chain I, K, L, T, V, X[auth Y]|16.a.26 Light chain|Homo sapiens (9606) DIQMTQSPVSLSASVGDRVTITCRASQSIGKFLNWYQQKPGRAPKLLIYYASNLETGGPSRFSGRGSETEFSLTISSLQPEDFATYYCQQSNNVPHTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: N
Mutation: NULL
| >5K9Q_N|Chain B, D, F, N, P, R|Hemagglutinin HA2|Influenza A virus (strain A/Hong Kong/1/1968 H3N2) (506350) FGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| S: ARG31 TYR54 THR55 GLY56 ASN57 LYS101 GLN102 GLY103 GLU104 VAL105 VAL106 LEU107 PRO108 ARG113 T: SER28 GLY30 LYS31 PHE32 TYR50 ARG65 SER67 GLU68 ASN92 N: ASP19 GLY20 TRP21 LEU38 LYS39 THR41 GLN42 ILE45 ASP46 ILE48 ASN49 LEU52 ASN53 ILE56 GLU57 LYS58 THR59 GLU61 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
