Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1475 |
| PDBID: | 5JW4 |
| Chains: | ST_H |
| Organism: | Influenza A virus (A/Vietnam/1194/2004(H5N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.70 |
| Reference: | 10.1016/j.cell.2016.05.073 |
| Antibody | |
| Antibody: | MEDI8852 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: S
Mutation: NULL
| >5JW4_S|Chain M, O, S, U, W|MEDI8852 heavy chain|Homo sapiens (9606) QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSYNAVWNWIRQSPSRGLEWLGRTYYRSGWYNDYAESVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCARSGHITVFGVNVDAFDMWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: T
Mutation: NULL
| >5JW4_T|Chain N, P, T, V, X|MEDI8852 light chain|Homo sapiens (9606) MTQSPSSLSASVGDRVTITCRTSQSLSSYTHWYQQKPGKAPKLLIYAASSRGSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: H
Mutation: NULL
| >5JW4_H|Chain B, D, F, H, J, L|Hemagglutinin|Influenza A virus (644788) GLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYPQY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition S: TYR32 VAL35 ARG52 TYR54 ARG56 SER57 TYR60 ASP62 GLU65 LYS68 VAL107 PHE108 GLY109 VAL110 ASN111 ASP113 T: GLN27 SER28 LEU29 SER30 SER31 TYR32 SER91 ARG92 H: GLN15 GLY16 VAL18 ASP19 GLY20 TRP21 GLN30 GLY31 SER32 GLY33 TYR34 LYS38 GLU39 THR41 GLN42 ILE45 ASP46 VAL48 THR49 VAL52 ASN146 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
