Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1462 |
| PDBID: | 5JO4 |
| Chains: | AB_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.53 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | anti-idiotype D80 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | G6 Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | Q6PYX1; P01857; P01859; P01861; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >5JO4_A|Chain A|D80 Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCRASGGTGGTFSAYAFTWVRQAPGQGLEWMGGITGMFGTANYAQKFQGRVTITADELTSTAYMELSSLTSEDTALYYCARGLYYYESSLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: B
Mutation: NULL
| >5JO4_B|Chain B|D80 Fab Light Chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQSLSSKYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYSCQQYDGVPRTFGQGTTVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >5JO4_C|Chain C|G6 Fab Heavy Chain|Homo sapiens (9606) QLVQSGAEVVKPGASVKVSCKASGYTFTSYWMHWVKQAPGQGLEWIGAVSPGNSDTSYNEKFKGKATLTVDKSASTAYMELSSLRSEDTAVYYCTRSRYGNNALDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: GLY30 THR31 PHE32 SER33 ALA34 TYR35 PHE37 ILE54 THR55 GLY56 MET57 PHE58 GLY59 THR60 ALA75 GLU77 TYR105 TYR106 C: TRP31 HIS33 TRP45 ALA48 SER50 ASN53 ASP55 SER57 SER97 ARG98 TYR99 GLY100 ASN101 ALA103 LEU104 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
