Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1460 |
| PDBID: | 5JMO |
| Chains: | C_A |
| Organism: | Homo sapiens, Camelus dromedarius, synthetic construct |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1038/srep34303 |
| Antibody | |
| Antibody: | Nb14 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Furin |
| Antigen mutation: | No |
| Durg Target: | P09958 |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >5JMO_C|Chain C, D|camelid VHH fragment|Camelus dromedarius (9838) QVQLQESGGGLVQPGGSLTLSCAASGFTFSSYSMYWVRQAPGKGLEWVSSINRVGSNTDYADSVKGRFTISRDNAKNTLYLQMNSLKSEDTALYYCAVGMYAAPPWRGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >5JMO_A|Chain A, B|Furin|Homo sapiens (9606) DVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTASGSLVPRGSHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER31 TYR32 SER33 TYR35 TRP47 SER50 ILE51 ASN52 ARG53 SER56 ASN57 ASP59 VAL98 GLY99 MET100 TYR101 ALA102 TRP106 A: THR456 GLU457 PRO458 ASP460 THR492 LEU493 SER494 TYR495 ASN496 ALA525 ASP526 PHE528 ASN529 ASN558 TYR560 GLY561 THR562 THR564 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
