Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 146 |
| PDBID: | 1QKZ |
| Chains: | HL_A |
| Organism: | Streptococcus sp. 'group G, Mus musculus, Neisseria meningitidis |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | 10.1006/jmbi.1999.3144 |
| Antibody | |
| Antibody: | MN14C11.6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Streptococcal protein G |
| Antigen mutation: | No |
| Durg Target: | P19909; P19909; P19909; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1QKZ_H|Chain B[auth H]|ANTIBODY|MUS MUSCULUS (10090) DVKLVESGGGLVKPGRSLKLSCAASGFTFSDYYMFWVRQTPEQRLEWVATISDGGAYTYYPDSVKGRFTISRDNAKNNLYLQMNSLKSEDTGMYYCARDPLEYYGMDYWGQGTSVAVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVNVTSSTWPSQSITCNVAHPASSTKVDKKIVPR |
Light Chain: L
Mutation: NULL
| >1QKZ_L|Chain C[auth L]|ANTIBODY|MUS MUSCULUS (10090) NIVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYTVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQSTHFPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGKERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: A
Mutation: NULL
| >1QKZ_A|Chain A|PROTEIN G-PRIME|STREPTOCOCCUS SP. (1320) MTPAVTTYKLVINGKTLKGETTTKAVDAATAEKVFKQYANDNGVDGEWTYDDATKTFTVTEKPE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR116 ALA118 PRO119 SER120 VAL121 TYR122 ALA201 SER202 SER203 THR204 LYS205 VAL206 ASP207 LYS208 LYS209 VAL211 L: GLU123 THR126 SER127 A: ILE12 LYS15 THR16 LEU17 LYS18 GLY19 GLU20 THR21 THR22 LYS24 TYR38 ASN40 ASP41 ASN42 GLY43 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
