Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1459 |
| PDBID: | 5JHL |
| Chains: | HL_A |
| Organism: | Zika virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1016/j.chom.2016.04.013 |
| Antibody | |
| Antibody: | 2A10G6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | zika virus envelope protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5JHL_H|Chain B[auth H]|Antibody Heavy chain|Mus musculus (10090) ASVLSEVQLQQSGPELVKPGASVKLSCKTSENTFTEYTMHWVKQSHGKSLEWIGGIDPNNGGTNYNQKFKGKATLTVDKSSNTAYMELRSLTSEDSAVYYCGRRDYYALDYWGQGTSVTVASAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGHHHHHH |
Light Chain: L
Mutation: NULL
| >5JHL_L|Chain C[auth L]|antibody Light chain|Mus musculus (10090) EFDIVMTQSQKFMSTSVGDRVSITCKASQHVGSAVAWYQQKPGQSPTLLIHSASNRYTGVPDRFTGSGSGTDFTLTISNIQSEDLADYFCQQYNSYPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNECS |
Antigen
Chain: A
Mutation: NULL
| >5JHL_A|Chain A|envelope protein|Zika virus (64320) MIRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTIGKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLU36 THR38 HIS40 TRP52 GLY55 ILE56 ASP57 ASN59 ASN60 GLY62 THR63 ASN64 ARG104 ALA108 LEU109 L: ALA34 GLN91 TYR93 ASN94 SER95 TYR96 PRO97 A: THR76 GLN77 ASP98 GLY100 TRP101 GLY102 GLY104 CYS105 GLY106 LEU107 PHE108 GLY109 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
