Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1446 |
| PDBID: | 5J1T |
| Chains: | C_A |
| Organism: | Homo sapiens, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 1.40 |
| Reference: | 10.7554/eLife.17983 |
| Antibody | |
| Antibody: | BS2 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Torsin-1A |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >5J1T_C|Chain C|VHH domain BS-2|Vicugna pacos (30538) MQVQLVETGGGLVQAGGSLRLSCAASGNIFSFNVMGWYRQAPGKQRELVAAITSGDTTTYADSVQGRFTISRDNAKNAVYLQMNSLTPEDTAVYFCNARRNPINGPYYTTAYWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >5J1T_A|Chain A|Torsin-1A|Homo sapiens (9606) GPGQKRSLSREALQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIYEGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDQMDKMHAGLIDAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHALSVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRVAEMTFFPKEERVFSDKGCKTVFTKLDYYYDD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: PHE30 SER31 ASN33 VAL34 THR53 SER54 GLY55 THR57 ASN101 PRO102 ILE103 ASN104 GLY105 PRO106 TYR107 A: HIS130 LEU131 PHE132 LEU136 HIS137 PHE138 HIS140 SER142 ASN143 LEU146 TYR147 GLN150 LEU151 TRP154 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
