Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1444 |
| PDBID: | 5J13 |
| Chains: | CB_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1038/ncomms14937 |
| Antibody | |
| Antibody: | Tezepelumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Tezepelumab(Approved) |
| Antigen | |
| Antigen: | Thymic stromal lymphopoietin |
| Antigen mutation: | No |
| Durg Target: | Q969D9 |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >5J13_C|Chain C|anti-TSLP Fab-fragment, heavy chain|Homo sapiens (9606) MGILPSPGMPALLSLVSLLSVLLMGCVAETGQMQLVESGGGVVQPGRSLRLSCAASGFTFRTYGMHWVRQAPGKGLEWVAVIWYDGSNKHYADSVKGRFTITRDNSKNTLNLQMNSLRAEDTAVYYCARAPQWELVHEAFDIWGQGTMVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKGTKHHHHHH |
Light Chain: B
Mutation: NULL
| >5J13_B|Chain B|anti-TSLP Fab-fragment, light chain|Homo sapiens (9606) MGILPSPGMPALLSLVSLLSVLLMGCVAETGSYVLTQPPSVSVAPGQTARITCGGNNLGSKSVHWYQQKPGQAPVLVVYDDSDRPSWIPERFSGSNSGNTATLTISRGEAGDEADYYCQVWDSSSDHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >5J13_A|Chain A|Thymic stromal lymphopoietin|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMYDFTNCDFEKIKAAYLSTISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINATQAMKKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ASP52 SER58 TRP59 C: MET5 GLY29 PHE30 THR31 ARG33 THR34 TYR35 TRP55 TYR56 ARG101 PRO103 GLN104 TRP105 GLU106 GLU110 A: ASN64 ASN65 THR66 VAL67 SER68 CYS69 SER70 ASN71 ARG72 HIS74 CYS75 GLU78 SER81 ARG150 ARG153 PRO154 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
