Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 144 |
| PDBID: | 1QFW |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1006/jmbi.1999.2845 |
| Antibody | |
| Antibody: | 3299 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | gonadotropin alpha subunit |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1QFW_H|Chain D[auth H]|ANTIBODY (ANTI ALPHA SUBUNIT) (HEAVY CHAIN)|Mus musculus (10090) QVQLQQSGAELVKPGASVKLSCKASDYTFTSYWMHWVKQRPGQGLEWIGEINPTNGRTYYNEKFKSKATLTVAASASTAAMQASSLTSEDSAVYYCARRYGNSFDYWGQGTTVTVSS |
Light Chain: L
Mutation: NULL
| >1QFW_L|Chain C[auth L]|ANTIBODY (ANTI ALPHA SUBUNIT) (LIGHT CHAIN)|Mus musculus (10090) DIELTQSPDSLAVSLGQRATISCRASESVDSYGNSFMQWYQQKPGQPPKLLIYRASNLESGIPARFSGTGSRTDFTLTINPVEADDVATYYCQQSDEYPYMYTFGGGTKLEIKR |
Antigen
Chain: A
Mutation: NULL
| >1QFW_A|Chain A|GONADOTROPIN ALPHA SUBUNIT|Homo sapiens (9606) APDTQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ASN34 SER35 PHE36 ARG54 SER95 ASP96 GLU97 TYR100 TYR102 H: THR30 SER31 TYR32 TRP33 PRO52 THR53 ASN54 ARG56 TYR59 ARG99 TYR100 GLY101 ASN102 A: GLU14 ASN15 PRO16 PHE17 PHE18 SER19 GLN20 PRO21 GLY22 GLN27 MET71 GLY72 PHE74 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
