Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 143 |
| PDBID: | 1QFU |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/X-31(H3N2)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1038/9299 |
| Antibody | |
| Antibody: | HC45 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1QFU_H|Chain D[auth H]|PROTEIN (IMMUNOGLOBULIN IGG1-KAPPA ANTIBODY (HEAVY CHAIN))|Mus musculus (10090) QVQLQQPGAELVRPGASVKLSCKASGYTLTTYWMNWFKQRPDQGLEWIGRIDPYDSETHYNQKFKDKAILTVDRSSSTAYMQLSSLTSEDSAVYYCTRFLQITTIIYGMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD |
Light Chain: L
Mutation: NULL
| >1QFU_L|Chain C[auth L]|PROTEIN (IMMUNOGLOBULIN IGG1-KAPPA ANTIBODY (LIGHT CHAIN))|Mus musculus (10090) DVVMTQTPLSLPVSLGDQASISCRSSQTLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYFCSQNTHVPYTFGGGTKLEIKRADAAPTVSIFPPSKIQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: A
Mutation: NULL
| >1QFU_A|Chain A|PROTEIN (HEMAGGLUTININ (HA1 CHAIN))|Influenza A virus (A/X-31(H3N2)) (132504) QDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR49 ARG54 PHE55 SER56 GLY57 PRO59 GLU81 H: GLN1 VAL2 GLY26 TYR27 THR28 THR30 THR31 TYR32 TYR53 ASP54 ARG94 LEU96 GLN97 ILE98 THR99 TYR102 A: THR48 GLY49 LYS50 ASN53 ILE58 LEU59 ASP60 ILE62 ASP63 PRO74 HIS75 ASP77 VAL78 PHE79 GLU82 ARG90 LYS92 PHE94 SER95 ASN96 ARG141 GLY142 PRO143 ASP271 PRO273 ILE274 ASP275 THR276 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
