Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1426 |
| PDBID: | 5IBL |
| Chains: | HL_B |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.39 |
| Reference: | 10.1038/nm.4223 |
| Antibody | |
| Antibody: | 6639 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5IBL_H|Chain C, G[auth H]|6639 Heavy Chain|Homo sapiens (9606) EVQLVQSGAEVKKPGESLTISCKGSGYSFSSYWIGWVRRMPGKGLEWMGIINPRDSDTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARVVADREGFGYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >5IBL_L|Chain D, H[auth L]|6639 Light Chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGEGATLSCRASQSVDSSSLAWYQQKPGQAPRLLIFAGSSRATGIPDRFSGKTSGTDFTLTISRLEPEDFAVYYCQQCGNSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >5IBL_B|Chain B, F|Hemagglutinin|Influenza A virus (11320) ADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSDKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGSSRYSKTFKPEIAIRPKVRDREGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNIPSIQSR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER31 ASP102 ARG103 GLU104 GLY105 PHE106 TYR108 TYR110 L: ASP30 SER31 SER32 PHE50 ALA51 SER53 SER54 B: TYR98 LYS133 VAL135 THR136 LYS145 TRP153 VAL155 LYS156 ASN159 HIS183 PRO185 SER186 THR187 SER188 ALA189 ASP190 GLN192 SER193 LEU194 GLN196 ILE219 LYS222 ASP225 ARG226 GLU227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
