Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 140 |
| PDBID: | 1PG7 |
| Chains: | ZY_M |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1016/s0022-2836(03)00735-6 |
| Antibody | |
| Antibody: | anti-idiotype 6A6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | humanized anti-tissue factor antibody D3H44 light chain |
| Antigen mutation: | No |
| Durg Target: | Q7Z3Y4; P01834; |
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >1PG7_Z|Chain F[auth X], H[auth Z]|murine antibody 6A6 Fab fragment|Mus musculus (10090) EVQLQQSGPELVKPGASVKISCKASGYSFTGHLLNWVKQSHGKNLEWIGLVHPHNGAITYNQKFKDKATLTVDRSSTTAYIELVRLTSNDSAVYYCAREDFRYHYSMDYWGQGTSVTVSSAKTTPPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSVTCNVAHPASSTKVDKKIVPK |
Light Chain: Y
Mutation: NULL
| >1PG7_Y|Chain E[auth W], G[auth Y]|murine antibody 6A6 Fab fragment|Mus musculus (10090) QAVVTQESALTSSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGVIGGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLGQPKSSPSVNLFPPSSEELKTKKATLVCTITEFYPGAVRVDWKADGTPVTQGDETTQPSKQSNNKYMASSYLTLTAEAWESHSSYSCHVTHEGQSVEKSLS |
Antigen
Chain: M
Mutation: NULL
| >1PG7_M|Chain C[auth L], D[auth M]|humanized antibody D3H44|Mus musculus (10090) DIQMTQSPSSLSASVGDRVTITCRASRDIKSYLNWYQQKPGKAPKVLIYYATSLAEGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCLQHGESPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Y: THR29 SER30 TYR32 TRP91 SER93 TRP96 Z: LEU33 LEU50 HIS53 ASN54 ALA56 THR58 GLU95 PHE97 ARG98 TYR99 M: ARG27 ASP28 LYS30 TYR32 TYR49 TYR50 THR52 SER53 GLU56 SER67 GLY68 HIS91 GLY92 GLU93 SER94 TRP96 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
