Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 14 |
| PDBID: | 1BZQ |
| Chains: | N_B |
| Organism: | Bos taurus, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1016/s0969-2126(99)80049-5 |
| Antibody | |
| Antibody: | cAb-Lys3 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | RNASE A |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: N
Mutation: NULL
| >1BZQ_N|Chain E[auth K], F[auth L], G[auth M], H[auth N]|PROTEIN (ANTIBODY CAB-RN05)|Camelus dromedarius (9838) QVQLVESGGGLVQAGGSLRLSCAASGYAYTYIYMGWFRQAPGKEREGVAAMDSGGGGTLYADSVKGRFTISRDKGKNTVYLQMDSLKPEDTATYYCAAGGYELRDRTYGQWGQGTQVTVSSRGR |
Antigen
Chain: B
Mutation: NULL
| >1BZQ_B|Chain A, B, C, D|PROTEIN (RNASE A)|Bos taurus (9913) KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| N: VAL1402 TYR1427 ALA1428 TYR1429 THR1430 TYR1431 ILE1432 TYR1433 GLY1499 GLY1500 TYR1501 ARG1504 ARG1506 THR1507 TYR1508 GLY1509 GLN1510 B: SER259 GLN260 LYS261 ASN262 VAL263 ALA264 GLY268 GLN269 THR270 ASN271 TYR273 TYR276 GLU311 GLY312 TYR315 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
