Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1392 |
| PDBID: | 5H37 |
| Chains: | KL_B |
| Organism: | Zika virus, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.00 |
| Reference: | 10.1038/ncomms13679 |
| Antibody | |
| Antibody: | C10 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | zika virus structural protein E |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >5H37_K|Chain G, I, K|C10 IgG heavy chain variable region|Homo sapiens (9606) EVQLVESGAEVKKPGASVKVSCKASGYTFTSYAMHWVRQAPGQRLEWMGWINAGNGNTKYSQKFQDRVTITRDTSASTAYMELSSLRSEDTAIYYCARDKVDDYGDYWFPTLWYFDYWGQGTLVTVS |
Light Chain: L
Mutation: NULL
| >5H37_L|Chain H, J[auth L], L[auth M]|C10 IgG light chain variable region|Homo sapiens (9606) SALTQPASVSGSPGQSITISCTGTSSDVGGFNYVSWFQQHPGKAPKLMLYDVTSRPSGVSSRFSGSKSGNTASLTISGLQAEDEADYYCSSHTSRGTWVFGGGTKLTVL |
Antigen
Chain: B
Mutation: NULL
| >5H37_B|Chain A, B, D[auth C]|structural protein E|Zika virus (64320) IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTIGKAFEATVRGAKRMAVLGDTAWDFGSVGGALNSLGKGIHQIFGAAFKSLFGGMSWFSQILIGTLLMWLGLNTKNGSISLMCLALGGVLIFLSTAVSA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition K: ASN56 LYS58 GLN61 GLN64 ASP98 L: GLY28 PHE29 ASN30 TYR31 SER92 ARG93 B: ASP67 MET68 ALA69 SER70 ASP71 SER72 ARG73 CYS74 THR76 GLN77 LEU82 ASP83 LYS84 VAL97 ASP98 ARG99 TRP101 GLY102 ASN103 GLY104 CYS105 GLY106 LEU113 THR115 HIS249 LYS251 ARG252 GLN253 THR254 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
