Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 139 |
| PDBID: | 1PG7 |
| Chains: | ZY_I |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1016/s0022-2836(03)00735-6 |
| Antibody | |
| Antibody: | anti-idiotype 6A6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | humanized anti-tissue factor antibody D3H44 heavy chain |
| Antigen mutation: | No |
| Durg Target: | Q6PYX1; P01857; P01859; P01860; P01861; |
Sequence information
Antibody
Heavy Chain: Z
Mutation: NULL
| >1PG7_Z|Chain F[auth X], H[auth Z]|murine antibody 6A6 Fab fragment|Mus musculus (10090) EVQLQQSGPELVKPGASVKISCKASGYSFTGHLLNWVKQSHGKNLEWIGLVHPHNGAITYNQKFKDKATLTVDRSSTTAYIELVRLTSNDSAVYYCAREDFRYHYSMDYWGQGTSVTVSSAKTTPPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSVTCNVAHPASSTKVDKKIVPK |
Light Chain: Y
Mutation: NULL
| >1PG7_Y|Chain E[auth W], G[auth Y]|murine antibody 6A6 Fab fragment|Mus musculus (10090) QAVVTQESALTSSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGVIGGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLGQPKSSPSVNLFPPSSEELKTKKATLVCTITEFYPGAVRVDWKADGTPVTQGDETTQPSKQSNNKYMASSYLTLTAEAWESHSSYSCHVTHEGQSVEKSLS |
Antigen
Chain: I
Mutation: NULL
| >1PG7_I|Chain A[auth H], B[auth I]|humanized antibody D3H44|Mus musculus (10090) EVQLVESGGGLVQPGGSLRLSCAASGFNIKEYYMHWVRQAPGKGLEWVGLIDPEQGNTIYDPKFQDRATISADNSKNTAYLQMNSLRAEDTAVYYCARDTAAYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Y: PRO56 Z: VAL2 GLY26 TYR27 SER28 THR30 GLY31 HIS32 HIS53 ARG94 ASP96 PHE97 ARG98 TYR99 I: GLU31 TYR33 LEU50 GLU53 GLN54 ASN56 ILE58 ASP95 THR96 ALA97 ALA98 TYR99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
