Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1386 |
| PDBID: | 5GZO |
| Chains: | CD_B |
| Organism: | Zika virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.75 |
| Reference: | 10.1126/scitranslmed.aai8336 |
| Antibody | |
| Antibody: | Z23 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika envelope protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >5GZO_C|Chain B[auth C], E[auth H]|Antibody heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSGTLSLTCAVSGGSISSSNWWSWVRQPPGKGLEWIGEIYHSGSTNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCARDRDDLSPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK |
Light Chain: D
Mutation: NULL
| >5GZO_D|Chain C[auth D], F[auth L]|Antibody light chain|Homo sapiens (9606) DIVMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASSLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYPRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS |
Antigen
Chain: B
Mutation: NULL
| >5GZO_B|Chain A, D[auth B]|Genome polyprotein|Zika virus (64320) IRCIGVSNRDFVEGMSGGTWVDVVLEHGGCVTVMAQDKPTVDIELVTTTVSNMAEVRSYCYEASISDMASDSRCPTQGEAYLDKQSDTQYVCKRTLVDRGWGNGCGLFGKGSLVTCAKFACSKKMTGKSIQPENLEYRIMLSVHGSQHSGMIVNDTGHETDENRAKVEITPNSPRAEATLGGFGSLGLDCEPRTGLDFSDLYYLTMNNKHWLVHKEWFHDIPLPWHAGADTGTPHWNNKEALVEFKDAHAKRQTVVVLGSQEGAVHTALAGALEAEMDGAKGRLSSGHLKCRLKMDKLRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTIGK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: SER30 SER31 SER32 TRP34 GLU51 TYR53 HIS54 SER55 SER57 THR58 ASN59 LYS74 ASP101 ASP102 LEU103 D: ILE2 GLN27 GLY28 ARG30 ASP32 HIS91 ASN92 SER93 TYR94 ARG96 B: SER64 ILE65 SER66 ASP67 MET68 ALA69 LYS84 ASP87 THR88 GLN89 TYR90 LYS118 PHE119 ALA120 SER122 GLY232 THR233 PRO234 LYS246 ARG252 THR254 VAL255 VAL256 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
