Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1375 |
| PDBID: | 5GGV |
| Chains: | HL_Y |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1038/ncomms13354 |
| Antibody | |
| Antibody: | tremelimumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Tremelimumab(Approved); Volrustomig(Phase-III); |
| Antigen | |
| Antigen: | Cytotoxic T-lymphocyte protein 4 |
| Antigen mutation: | No |
| Durg Target: | P16410 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >5GGV_H|Chain B[auth H]|heavy chain|Homo sapiens (9606) QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYGMHWVRQAPGKGLEWVAVIWYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDPRGATLYYYYYGMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTHHHHHH |
Light Chain: L
Mutation: NULL
| >5GGV_L|Chain A[auth L]|light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSINSYLDWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYYSTPFTFGPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: Y
Mutation: NULL
| >5GGV_Y|Chain C[auth Y]|Cytotoxic T-lymphocyte protein 4|Homo sapiens (9606) KAMHVAQPAVVLASSRGIASFVCEYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: GLN27 SER28 ASN30 TYR32 TYR91 TYR92 SER93 THR94 PHE96 H: TRP52 TYR53 ASN57 TYR59 LYS65 ARG101 GLY102 ALA103 THR104 LEU105 TYR106 TYR107 TYR108 TYR110 Y: LYS1 ALA2 MET3 PRO28 GLU33 ARG35 LEU39 GLN41 SER44 GLN45 VAL46 GLU48 LEU91 ILE93 LYS95 GLU97 MET99 PRO102 PRO103 TYR104 TYR105 LEU106 GLY107 ILE108 GLY109 ASN110 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
