Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 135 |
| PDBID: | 1P2C |
| Chains: | BA_C |
| Organism: | Mus musculus, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1073/pnas.0400060101 |
| Antibody | |
| Antibody: | F10.6.6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hen Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1P2C_B|Chain B, E|heavy chain VH+CH1 anti-lysozyme antibody F10.6.6|Mus musculus (10090) EVQLQESGAELMKPGASVKISCKATGYTFTTYWIEWIKQRPGHSLEWIGEILPGSDSTYYNEKVKGKVTFTADASSNTAYMQLSSLTSEDSAVYYCARGDGFYVYWGQGTTLTVSSASTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPWPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: A
Mutation: NULL
| >1P2C_A|Chain A, D|light chain anti-lysozyme antibody F10.6.6|Mus musculus (10090) DIELTQSPATLSVTPGDSVSLSCRASQSISNNLHWYQQKSHESPRLLIKYTSQSMSGIPSRFSGSGSGTDFTLSINSVETEDFGVYFCQQSGSWPRTFGGGTKLDIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: C
Mutation: NULL
| >1P2C_C|Chain C, F|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLN27 ILE29 ASN32 TYR50 SER91 GLY92 SER93 TRP94 ARG96 B: THR330 THR331 TYR332 TRP333 GLU335 GLU350 LEU352 SER355 ASP356 SER357 THR358 TYR359 GLY399 ASP400 GLY401 C: GLN641 THR643 ARG645 ASN646 THR647 ASP648 GLY649 SER650 THR651 TYR653 ASN665 ASP666 GLY667 ARG668 PRO670 PRO679 SER681 LEU684 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
