Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1347 |
| PDBID: | 5FHC |
| Chains: | AB_J |
| Organism: | Ebola virus - Mayinga, Zaire, 1976, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 6.70 |
| Reference: | 10.1126/science.aad6117 |
| Antibody | |
| Antibody: | 100 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ebola Virus Fusion Glycoprotein (GP) |
| Antigen mutation: | No |
| Durg Target: | Q05320 |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >5FHC_A|Chain C[auth A]|Antibody 100 Fab heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSDTLSLTCTVSGGSLSSFYWSWIRQPPGKGLEWIGYIYYSGSPNYSPSLESRVTMSVDTTRNQISLKLDSVTAADTAVYYCVRASRSYYWGSYRPTAFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS |
Light Chain: B
Mutation: NULL
| >5FHC_B|Chain D[auth B]|Antibody 100 Fab light chain|Homo sapiens (9606) YELTQPLSVSVSPGQTAIFTCSGDNLGDKYVCWFQQRPGQSPMLLIYQDNKRPSGIPERFSGSNSGNTATLTISGTQSTDEADYYCQTWDSTVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT |
Antigen
Chain: J
Mutation: NULL
| >5FHC_J|Chain A[auth J]|Envelope glycoprotein|Zaire ebolavirus (strain Mayinga-76) (128952) EAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYIEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: SER31 PHE32 ARG94 SER96 ARG97 SER98 ASP101 B: LEU46 TYR49 GLN50 LYS53 PRO55 J: GLU523 GLY524 ALA526 ILE527 GLY528 LEU529 TRP531 ILE544 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
