Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1343 |
| PDBID: | 5FB8 |
| Chains: | BA_C |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.07 |
| Reference: | 10.1074/jbc.M115.709303 |
| Antibody | |
| Antibody: | 14.1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Pro-interleukin-16 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >5FB8_B|Chain B|Anti-IL-16 antibody 14.1 Fab domain Heavy Chain|Mus musculus (10090) EVQLQQSGPELVKPGASMKISCKASGYSFTGYTMNWVKQSHGKNLEWIGLINPYNSGTNYNQKFKDKATLIVDKSSNTAYMELLSLTSEDSAVYYCARSDYYDSTHYFDYWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: A
Mutation: NULL
| >5FB8_A|Chain A|Anti-IL-16 antibody 14.1 Fab domain Kappa Chain|Mus musculus (10090) DIVLTQSPASLAVSLGQRATISCRASKSVSTSGYSYMHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCQHSRELPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >5FB8_C|Chain C|Pro-interleukin-16|Homo sapiens (9606) SMVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: THR56 SER57 GLY58 TYR59 TYR61 TYR78 LEU79 ASN82 GLU84 SER85 B: GLY46 TYR47 SER48 THR50 GLY51 TYR52 ASN72 TYR74 ASN75 ASP120 TYR121 TYR122 ASP123 SER124 THR125 TYR127 ASP129 C: MET38 SER39 ALA40 GLY41 LEU42 GLY43 PHE44 SER45 LEU46 GLU47 GLY51 SER52 LEU53 ASN62 ARG63 ILE64 PHE65 LYS66 THR94 ARG95 PHE96 GLU97 TRP99 ILE102 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
