Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 13 |
| PDBID: | 1BZQ |
| Chains: | L_A |
| Organism: | Bos taurus, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1016/s0969-2126(99)80049-5 |
| Antibody | |
| Antibody: | cAb-Lys3 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | RNASE A |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: L
Mutation: NULL
| >1BZQ_L|Chain E[auth K], F[auth L], G[auth M], H[auth N]|PROTEIN (ANTIBODY CAB-RN05)|Camelus dromedarius (9838) QVQLVESGGGLVQAGGSLRLSCAASGYAYTYIYMGWFRQAPGKEREGVAAMDSGGGGTLYADSVKGRFTISRDKGKNTVYLQMDSLKPEDTATYYCAAGGYELRDRTYGQWGQGTQVTVSSRGR |
Antigen
Chain: A
Mutation: NULL
| >1BZQ_A|Chain A, B, C, D|PROTEIN (RNASE A)|Bos taurus (9913) KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: VAL1002 TYR1027 ALA1028 TYR1029 THR1030 TYR1031 ILE1032 TYR1033 GLY1099 GLY1100 TYR1101 ARG1104 ARG1106 THR1107 TYR1108 GLY1109 GLN1110 A: SER59 GLN60 LYS61 ASN62 VAL63 ALA64 GLY68 GLN69 THR70 ASN71 TYR73 TYR76 GLU111 GLY112 TYR115 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
