Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 1299 |
| PDBID: | 5F1K |
| Chains: | C_A |
| Organism: | Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1038/srep27055 |
| Antibody | |
| Antibody: | MU1053 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(CD38) |
| Antigen mutation: | No |
| Durg Target: | P28907 |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >5F1K_C|Chain C, D|nanobody MU1053|Lama glama (9844) DVQLQESGGGLVQAGGSLRLSCTGSGRTFRNYPMAWFRQAPGKEREFVAGITWVGASTLYADFAKGRFTISRDNAKNTVYLQMNSLKPEDTAVYSCAAGRGIVAGRIPAEYADWGQGTQVTVSSEPKTPKPQPAAAHHHHHHGAAEQKLISEEDLNGAA |
Antigen
Chain: A
Mutation: NULL
| >5F1K_A|Chain A, B|ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1|Homo sapiens (9606) RWRQTWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCDITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFDTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLDGSRSKIFDKDSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: ARG27 ARG30 ASN31 TYR32 THR52 TRP53 VAL54 GLY55 ALA56 SER57 THR58 LEU59 TYR60 LYS65 ARG100 GLY101 ILE102 VAL103 ALA104 GLY105 ARG106 A: ASN120 LYS121 PHE135 GLN139 ASP141 MET142 ASP202 VAL203 HIS205 PRO232 GLU233 LYS234 GLN236 THR237 GLU239 TRP241 GLN272 SER274 CYS275 LYS276 ILE278 PHE284 CYS287 VAL288 PRO291 GLU292 ASP293 SER294 CYS296 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
